Candidate Genes Diabetic Retinopathy

Adiponectin

Official Symbol
AGER
Alternative Names
OTTHUMP00000029155
OTTHUMP00000029156
OTTHUMP00000174885
RAGE isoform sRAGE-delta
RAGE isoform NtRAGE-delta
Description
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene
Location
6p21.3
Map
Chr 17
Start: 32,148,745 bp from pter
End: 32,152,101 bp from pter
Size: 3,357 bases
Orientation: minus strand
Exons and Introns
11 exons and 32 distinct introns (29 gt-ag, 3 gc-ag).
Location
1391 bp
Nucleotide Sequence
Aminoacid Sequence
Variation
rs184003 G/T
Motif
Pfam: C2-set_2 I-set ig V-set DUF1191 C2-set
PROSITE: IG_MHC IG_LIKE
Interactors
Protein interactors
Transthyretin
Calgranulin C
S100 calcium binding protein P
S100 alpha
High mobility group box 1
Post Translational Modification
Disulfide bond
Glycosylation
Molecular Weight
42803 da
Molecular Class
Cell surface receptor
Molecular Function
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space
3D Structure