Candidate Genes Diabetic Retinopathy

Angiotensin II receptor, type 1

Official Symbol
AGTR1
Alternative Names
angiotensin receptor 1
angiotensin receptor 1B
angiotensin II type-1 receptor
type-1B angiotensin II receptor
AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT1R, AT2R1, AT2R1A, AT2R1B, HAT1R
Description
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene.
Location
3q24
Map
Chr 17
Start: 148,415,571 bp from pter
End: 148,460,795 bp from pter
Size: 45,225 bases
Orientation: plus strand
Exons and Introns
3 exons and 4 distinct introns (13 gt-ag, 1 gc-ag).
Nucleotide Sequence
Aminoacid Sequence
Variation
rs5182 C/T
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx
PROSITE: G_PROTEIN_RECEP_F1_1 G_PROTEIN_RECEP_F1_2
Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin-angiotensin system
Interactors
Protein interactors
Beta adrenergic receptor kinase 2
EGF receptor
RAF1
Dopamine receptor interacting protein
H-Ras
Phospholipase C, gamma 1
Post Translational Modification
C-terminal Ser or Thr residues may be phosphorylated
Disulfide bond
Glycoprotein
Lipoprotein
Palmitate
Molecular Weight
41061 da
Molecular Class
G protein coupled receptor
Molecular Function
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system Transducer
3D Structure