Candidate Genes Diabetic Retinopathy

Aldo-keto reductase family 1, member B10 (aldose reductase)

Official Symbol
AKR1B10
Alternative Names
ARP
hARP
SI reductase
OTTHUMP00000207788
aldose reductase-like 1
small intestine reductase
aldose reductase-like peptide
aldose reductase-related protein
aldo-keto reductase family 1, member B11 (aldose reductase-like)
AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, MGC14103
Description
Aldose reductase is an NADPH-dependent enzyme that was first identified by its ability to reduce glucose to sorbitol. The deduced 316-amino acid AKR1B10 protein shares 71% amino acid identity with AR. AKR1B10 is expressed most abundantly in small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis
Location
7q33
Map
Chr 17
Start: 134,212,344 bp from pter
End: 134,226,166 bp from pter
Size: 13,823 bases
Orientation: plus strand
Exons and Introns
10 exons and 16 distinct gt-ag introns
Nucleotide Sequence
Aminoacid Sequence
Variation
rs697534 C/G
Motif
Pfam: Aldo_ket_red IIGP
PROSITE:ALDOKETO_REDUCTASE_2 ALDOKETO_REDUCTASE_1 ALDOKETO_REDUCTASE_3
Ec No.
1.1.1.2
Biophysico Properties
Kinetic parameters:
KM=600 ÁM for D,L-glyceraldehyde
KM=0.6 ÁM for all-trans-retinaldehyde
KM=0.7 ÁM for 9-cis-retinaldehyde
Enzyme Regulation
Inhibited by tolrestat
Pathway
Fructose and mannose metabolism
Linoleic acid metabolism
Butanoate metabolism
Post Translational Modification
Acetylation
Phosphorylation
Molecular Weight
36020 da
Molecular Class
Enzyme: Reductase
Molecular Function
Catalytic activity Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs
3D Structure