Candidate Genes Diabetic Retinopathy

Angiopoietin 2

Official Symbol
ANGPT2
Alternative Names
ANG-2
Tie2-ligand
angiopoietin-2B
angiopoietin-2a
OTTHUMP00000115423
OTTHUMP00000224502
OTTHUMP00000224503
Description
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
Location
8p23.1
Map
Chr 17
Start: 6,357,172 bp from pter
End: 6,420,930 bp from pter
Size: 63,759 bases
Orientation: minus strand
Exons and Introns
9 exons and 10 distinct gt-ag introns.
Nucleotide Sequence
Aminoacid Sequence
Variation
rs151307848 A/G
Motif
Pfam: Fibrinogen_C V_ATPase_I SlyX DivIC
PROSITE: FIBRIN_AG_C_DOMAIN
Interactors
Protein interactors
Angiopoietin1
Angiopoietin 2
TEK receptor tyrosine kinase
Post Translational Modification
Disulfide bond
Glycosylation
Molecular Weight
56919 da
Molecular Class
Ligand
Molecular Function
Developmental protein Receptor binding Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal
3D Structure