Candidate Genes Diabetic Retinopathy

Apelin

Official Symbol
APLN
Alternative Names
AGTRL1 ligand
APJ endogenous ligand
Description
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
Location
Xq25
Map
Chr 17
Start: 128,779,236 bp from pter
End: 128,788,933 bp from pter
Size: 9,698 bases
Orientation: minus strand
Exons and Introns
3 exons and 4 distinct gt-ag introns.
Nucleotide Sequence
Aminoacid Sequence
Variation
rs734975 G/A
Interactors
Protein interactors
Angiotensin receptor like 1
Post Translational Modification
Several active peptides may be produced by proteolytic processing of the peptide precursor Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Molecular Weight
8569 da
Molecular Class
Ligand
Molecular Function
Receptor binding Hormone Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.
3D Structure