Candidate Genes Diabetic Retinopathy

Apelin receptor

Official Symbol
APLNR
Alternative Names
APJ receptor
HG11 orphan receptor
APJ (apelin) receptor
angiotensin receptor-like 1
G protein-coupled receptor APJ
angiotensin II receptor-like 1
G-protein coupled receptor HG11
Description
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified
Location
11q12
Map
Chr 17
Start: 57,001,051 bp from pter
End: 57,004,927 bp from pter
Size: 3,877 bases
Orientation: minus strand
Exons and Introns
1 exon and 1 gt-ag intron
Nucleotide Sequence
Aminoacid Sequence
Variation
rs746885 G/A
Motif
Pfam: 7tm_1 7TM_GPCR_Srv TAS2R
PROSITE: G_PROTEIN_RECEP_F1_1 G_PROTEIN_RECEP_F1_2
Pathway
Neuroactive ligand-receptor interaction
Interactors
Protein interactors
Apelin
Post Translational Modification
Glycosylation
Molecular Weight
42660 da
Molecular Class
G protein coupled receptor
Molecular Function
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection May be involved in the development of AIDS dementia. Transducer
3D Structure