Candidate Genes Diabetic Retinopathy

Apolipoprotein A-I

Official Symbol
APOA1
Alternative Names
apolipoprotein A-I
apo-AI
apoA-I
OTTHUMP00000043268
Description
APOA1 gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis
Location
11q23-q24
Map
Chr 17
Start: 116,706,467 bp from pter
End: 116,708,666 bp from pter
Size: 2,200 bases
Orientation: minus strand
Exons and Introns
4 exons and 9 distinct introns (8 gt-ag, 1 other).
Nucleotide Sequence
Aminoacid Sequence
Variation
rs670 G/A
Motif
Pfam: Apolipoprotein ApoC-I YtxH DUF883 DUF3618 OmpH ApoLp-III DUF2894 Gp58 RRF DUF445 Exonuc_VII_L Prominin Transposase_22 KMP11 Bacillus_HBL ISG65-75 DUF1664 DUF2959 DUF2317 Cob_adeno_trans GrpE FlgN
Pathway
PPAR signaling pathway
Pathway
Fat digestion and absorption
Pathway
Vitamin digestion and absorption
Interactors
Protein interactors
Lipopolysaccharide binding protein
Phosphodiesterase 1A
TOM20
Transthyretin
TRAIL receptor 3
Paraoxonase 1
Post Translational Modification
Palmitoylated.
Phosphorylation sites are present in the extracelllular medium
Glycation
Glycosylation
Lipoprotein
Molecular Weight
30778 da
Molecular Class
Transport/cargo protein
Molecular Function
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues Act as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility
3D Structure