Candidate Genes Diabetic Retinopathy

Rho GTPase activating protein 22

Official Symbol
ARHGAP22
Alternative Names
OTTHUMP00000019561
OTTHUMP00000217290
rho-type GTPase-activating protein 22
Description
ARHGAPs, such as ARHGAP22, encode negative regulators of Rho GTPases which are implicated in actin remodeling, cell polarity, and cell migration.
Location
10q11.22
Map

Start:49,654,077 bp from pter
End: 49,864,310 bp from pter
Size: 210,234 bases
Orientation: minus strand
Exons and Introns
14 exons and 23 distinct gt-ag introns.
Nucleotide Sequence
Aminoacid Sequence
Variation
rs730509 G/T
Motif
Pfam: RhoGAP PH IncA Tropomyosin_1 ADIP Atg14
PROSITE: SER_RICH PH_DOMAIN RHOGAP
Post Translational Modification
Phosphorylation
Molecular Weight
76779 da
Molecular Class
GTPase activating protein
Molecular Function
Involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter
3D Structure