Candidate Genes Diabetic Retinopathy

Fatty acid binding protein 2, intestinal

Official Symbol
FABP2
Alternative Names
fatty acid-binding protein, intestinal
OTTHUMP00000163925
fatty acid-binding protein 2
intestinal-type fatty acid-binding protein
FABPI, I-FABP, MGC133132
Description
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.
Location
4q28-q31
Map
Chr 17
Start: 120,238,405 bp from pter
End: 120,243,545 bp from pter
Size: 5,141 bases
Orientation: minus strand
Exons and Introns
4 exons and 4 distinct gt-ag introns.
Nucleotide Sequence
Aminoacid Sequence
Variation
rs2964 T/C
Motif
Pfam: Lipocalin
PROSITE: FABP
Induction
By EGF
pathway
PPAR signaling pathway
pathway
Fat digestion and absorption
Post Translational Modification
Acetylation
Molecular Weight
15237 da
Molecular Class
Transport/cargo protein
Molecular Function
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
3D Structure