Candidate Genes Diabetic Retinopathy

Intercellular adhesion molecule 1

Official Symbol
ICAM1
Alternative Names
BB2; CD54; P3.58; ICAM-1; human rhinovirus receptor; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
Description
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. Intercellular adhesion molecule-1 (ICAM1) is a ligand for lymphocyte function-associated (LFA) antigens.
Location
19p13.3-p13.2
Map
Chr 17
Start: 10,381,517 bp from pter
End: 10,397,291 bp from pter
Size: 15,775 bases
Orientation: plus strand
Exons and Introns
7 exons and 11 distinct introns (10 gt-ag, 1 other)
Nucleotide Sequence
Aminoacid Sequence
Variation
rs5490 A/C
Motif
Pfam: ICAM_N C2-set_2 I-set
Pathway
Cell adhesion molecules (CAMs
Pathway
Natural killer cell mediated cytotoxicity
Pathway
Leukocyte transendothelial migration
Interactors
Protein Interactors
Ezrin
Interleukin 2 receptor, alpha
Interleukin 2 receptor, gamma
Moesin
Sialophorin
Post Translational Modification
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis Disulfide bond Glycoprotein Phosphoprotein Ubl conjugation
Molecular Weight
57825 da
Molecular Class
Adhesion molecule
Molecular Function
Host cell receptor for virus entry ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus, infection acts as a cellular receptor for the virus
3D Structure