Candidate Genes Diabetic Retinopathy

Potassium channel, subfamily K, member 1

Official Symbol
Alternative Names
DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1; OTTHUMP00000036029; potassium channel KCNO1; inward rectifying potassium channel protein TWIK-1; potassium inwardly-rectifying channel, subfamily K, member 1
KCNK1 is a potassium-selective, pH-sensitive, openly rectifying channel regulated by sumoylation. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.
Chr 17
Start: 233,749,750 bp from pter
End: 233,808,258 bp from pter
Size: 58,509 bases
Orientation: plus strand
Exons and Introns
3 exons and 14 distinct gt-ag introns.
Nucleotide Sequence
Aminoacid Sequence
rs16360 TA/-
Pfam:Ion_trans_2 Ferric_reduct Ion_trans Bac_transf
Protein Interactors
Sentrin specific protease 1
Ubiquitin conjugating enzyme E2I
Potassium channel subfamily K member 1
Post Translational Modification
Phosphorylation Glycosylation
Molecular Weight
38143 da
Molecular Class
Inward rectifier channel
Molecular Function
Weakly inward rectifying potassium channel Ionic channel Potassium channel Voltage-gated channel
3D Structure