Candidate Genes Diabetic Retinopathy

Mitogen-activated protein kinase 3

Official Symbol
MAPK3
Alternative Names
ERK1;
PRKM3;
P44ERK1;
P44MAPK;
HS44KDAP;
HUMKER1A;
MGC20180 MAP kinase isoform p44;
insulin-stimulated MAP2 kinase;
mitogen-activated protein kinase 1;
extracellular signal-related kinase 1;
extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase;
ERT2; ERK-1;
MAPK 1;
p44-ERK1;
p44-MAPK; MAP kinase 1;
MAP kinase 3
Description
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described
Location
16p11.2
Map
Chr 17
Start: 30,125,426 bp from pter
End: 30,134,827 bp from pter
Size: 9,402 bases
Orientation: minus strand
Exons and Introns
9 Exon(s) and 18 distinct introns (17 gt-ag, 1 gc-ag)
Nucleotide Sequence
Aminoacid Sequence
Variation
rs1143695 G/A
Motif
Pfam: Pkinase Pkinase_Tyr APH Kdo essB Choline_kinase
PROSITE: MAPK PROTEIN_KINASE_ST PROTEIN_KINASE_ATP PROTEIN_KINASE_DOM
Ec No.
2.7.11.24
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein
Cofactor
Magnesium
Enzyme Regulation
Activated by tyrosine phosphorylation in response to insulin and NGF
Pathway
MAPK signaling pathway
Pathway
ErbB signaling pathway
Pathway
Oocyte meiosis
Pathway
TGF-beta signaling pathway
Pathway
Type II diabetes mellitus
Interactors
Protein interactors
beta arrestin 1
c Jun
Calcipressin 1
Connexin 43
DCC
ELK 1
ETS1
GAB2
Post Translational Modification
Phosphorylated upon FLT3 signaling. Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme. Dephosphorylated by PTPRJ at Tyr-204 Acetylation
Molecular Weight
43135 da
Molecular Class
Serine/threonine kinase
Molecular Function
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation.
Phosphorylates microtubule-associated protein 2 (MAP2).
Phosphorylates SPZ1.
Phosphorylates heat shock factor protein 4 (HSF4).
Kinase Transferase
3D Structure