Candidate Genes Diabetic Retinopathy

Placental growth factor

Official Symbol
PGF
Alternative Names
PGFL;
PLGF;
PlGF-2;
D12S1900;
SHGC-10760;
placental growth factor-like;
placental growth factor, vascular endothelial growth factor-related protein
Description
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene
Location
14q24.3
Map
Chr 17
Start: 75,408,537 bp from pter
End: 75,422,291 bp from pter
Size: 13,755 bases Orientation: minus strand
Exons and Introns
7 exons and 9 distinct gt-ag introns
Nucleotide Sequence
Aminoacid Sequence
Variation
rs8185 A/G
Motif
Pfam: PDGF
PROSITE: PDGF_1 PDGF_2
Pathway
mTOR signaling pathway
Pathway
Focal adhesion
Pathway
Pathways in cancer
Interactors
Protein interactors
VEGF A
VEGF receptor 1
Neuropilin 1
Neuropilin 2
Placental growth factor
Post Translational Modification
Disulfide bond
Glycosylation
Molecular Weight
19338 da
Molecular Class
Growth factor
Molecular Function
Developmental protein Mitogen Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. Binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
3D Structure