Candidate Genes Diabetic Retinopathy

Selectin E

Official Symbol
SELE
Alternative Names
ELAM;
ESEL;
CD62E;
ELAM1;
LECAM2;
endothelial adhesion molecule 1;
CD62 antigen-like family member E;
endothelial leukocyte adhesion molecule 1;
leukocyte endothelial cell adhesion molecule 2
Description
Cellular adhesion molecules (CAMs) are a large family of proteins that attach the cytoskeleton and intracellular signalling cascades with the extracellular environment. CAMs have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture, and their dysregulation is common in cancer. The selectins are Ca2+-dependent CAMs that bind fucosylated carbohydrates (e.g. mucins). There are three types of selectins, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet). The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. Endothelial leukocyte adhesion molecule-1 is expressed by cytokine-stimulated endothelial cells. It is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features homologous to those of LYAM1, including the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules.
Location
1q22-q25
Map
Chr 17
Start: 169,691,781 bp from pter
End: 169,703,220 bp from pter
Size: 11,440 bases
Orientation: minus strand
Exons and Introns
14 exons and 30 distinct gt-ag introns
Nucleotide Sequence
Aminoacid Sequence
Variation
rs4786 A/G
Motif
Pfam: Sushi Lectin_C EGF EGF_2 EGF_3 HRM
PROSITE: EGF_1 EGF_2 C_TYPE_LECTIN_1 EGF_3 C_TYPE_LECTIN_2 SUSHI
Pathway
Cell adhesion molecules (CAMs)
Interactors
Protein interactors
Actinin alpha 2
CD44
SHP2
Vinculin
Filamin A
Selectin P ligand
Paxillin
Post Translational Modification
Phosphorylation
dephosphorylation
Disulfide bond
Glycosylation
Molecular Weight
66655 da
Molecular Class
Adhesion molecule
Molecular Function
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis
3D Structure