Candidate Genes Diabetic Retinopathy

TGF-beta activated kinase 1/MAP3K7 binding protein 2

Official Symbol
TAB2
Alternative Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;
TAB-2; OTTHUMP00000017388;
TAK1-binding protein 2;
TGF-beta-activated kinase 1-binding protein 2;
mitogen-activated protein kinase kinase kinase 7-interacting protein 2
Description
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts
Location
6q25.1
Map
Chr 17
Start: 149,639,063 bp from pter
End: 149,732,749 bp from pter
Size: 93,687 bases
Orientation: plus strand
Exons and Introns
9 exons and 8 introns
Nucleotide Sequence
Aminoacid Sequence
Variation
rs151306177 A/G
Motif
Pfam: CUE zf-RanBP DivIC IncA
PROSITE: ZF_RANBP2_1 CUE ZF_RANBP2_2
Cofactor
Metal-binding Zinc
Pathway
MAPK signaling pathway
Pathway
Osteoclast differentiation
Pathway
Toll-like receptor signaling pathway
Pathway
NOD-like receptor signaling pathway
Interactors
Protein interactors
Apoptosis inhibitor 3
Interleukin 1 receptor associated kinase 1
MAP3K7
NUMBL
TRAF6
Histone deacetylase 3
Nuclear hormone receptor TR4
Mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Citrate synthase
Post Translational Modification
Phosphorylation Ubl conjugation
Molecular Weight
76494 da
Molecular Class
Adapter molecule
Molecular Function
K63-linked polyubiquitin binding Receptor signaling complex scaffold activity Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 Promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development
3D Structure